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However, if someone already has extremely high levels of vitamin B (from taking excessive supplements and showing toxicity symptoms), further pyridoxine would be avoided
Clinical improvement was also observed in oxidative stress markers, with improvements in methionine levels (p=0.05), homocysteine levels (SAH, p=0.007) and the ratio of S-adenosylmethionine (SAMe) to SAH (p=0.007), indicating improvement with methylation at the cellular level and a decrease in oxidative stress in the body 2
Second, there was no control group, so we cant rule out the possibility that the patients would have improved over time anyway
Cycle Length: 36 months typical for adult research use
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