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Central nervous system effects also contribute to emetic symptoms
Presented for research literature review only Maro JC et al
In addition to demonstrating the pharmacokinetics and pharmacodynamics of these hydrogel-based GLP-1 RA treatments, we have leveraged compartment modeling to demonstrate that a single administration of these drug product candidates can potentially provide upwards of four months of continuous therapy in humans
ZUPREME-1 Phase 2 used five weekly dose arms with q4w escalation
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