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For comparison, the Wegovy trials reported nausea at approximately 44% and the Zepbound trials at approximately 28%
For patients with a history of cardiovascular events without heart failure, metformin, SGLT2 inhibitors, or GLP-1 RAs are recommended as first-line and DPP4 inhibitors, pioglitazone, acarbose, or insulin as second-line treatment [5]
However, the authors included only six RCTs involving tirzepatide and, as opposed to our meta-analysis, did not provide information on comparative effects across different doses of the two medications [55]
Its taken as a daily injection, and your dosage will be carefully monitored and adjusted by your healthcare provider to meet your needs, depending on how your body responds
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