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You should exercise extreme caution or avoid the combination if you fall into the following categories: Pregnancy or Breastfeeding: There is insufficient safety data for the use of berberine or semaglutide during pregnancy

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Efpeglenatide has the potential to expand beyond obesity into diabetes, cardiovascular and kidney disease, and other metabolic conditions, Kim said

Bloating and Abdominal Discomfort Gas, fullness, and abdominal pain are frequently reported with semaglutide, especially during dose increases