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This was established by Baar and colleagues, who designed the FOXO4-DRI peptide to disrupt the FOXO4p53 interaction, causing nuclear exclusion of p53 and apoptosis in senescent cells (Cancer Discovery summary of the 2017 Cell paper)
Assistant Professor Nutrition Research Institute University of North Carolina at Chapel Hill Copyright 2000-2026 Linus Pauling Institute Figure Alternative Text Figure 1
However, as research into the mechanisms of Gln metabolism in tumor cells advances, the application of Gln metabolism imaging technology is expected to expand
PMID 30261596
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