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5,17 Endothelial cells (ECs), key mediators of vascular lesions, absorb excess glucose via insulin-independent pathways, such as glucose transporter 1-3 (GLUT1-3), resulting in elevated intracellular glucose levels

By inhibiting NNMT, 5-Amino-1MQ has been observed in models to elevate NAD+, activate downstream metabolic regulators, and support pathways that encourage higher energy expenditure and reduced adiposity