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TMAO is unreliable as a standalone biomarker due to the significant influence and variability of liver function, diet, gut microbiota diversity, and genetic factors
The improvement in TAS, GSH, TOS, GSSG, and MDA levels, which are oxidative stress markers, can be considered an indication that losartan has a protective and curative effect by reducing oxidative stress in hepatotoxicity induced by acetaminophen
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