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Because the pharmacokinetics are well understood and down-stream metabolites are easily quantifiable from urine, APAP is often used as a test case for the application of metabolic profiling in contexts as diverse as epidemiology (Loo et al
Sexual medicine reviews, 6(1), 4553
269 These findings illustrate that PERK signaling exerts dose-, duration-, and context-dependent effects, complicating efforts to therapeutically manipulate this pathway
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