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Subsequently, GLP-1s gained FDA approval for weight loss in 2014 (liraglutide: Saxenda/Victoza), 2021 (semaglutide: Wegovy/Ozempic/Rybelsus), and 2023 (tirzepatide: Zepbound/Mounjaro)
Large meals, greasy foods, fried foods, very rich meals, alcohol, carbonated drinks, and heavy late-night eating may sit in the stomach longer and trigger nausea, reflux, burping, or vomiting
Zhang S, Wu Z, Heng J, Tian M, Chen J, Chen F, et al
Insulin dose reduction of 20 to 50% at triple agonist initiation is consistent with the approach used in tirzepatide trials: the SURPASS-5 trial (N=475) reduced insulin glargine by 20% at tirzepatide initiation, which reduced hypoglycemia without sacrificing glycemic control
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