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The mechanistic core is thus comparable, but the pharmacokinetic implementation is fundamentally different
For example, after 2 years of treatment with liraglutide 2.4/3.0 mg in patients with obesity, 52% and 26% maintained at least 5% and at least 10% weight loss, respectively, compared with 29% and 16% of patients receiving orlistat [47] (Table 1)
For nausea and general gastrointestinal discomfort , multi-strain formulations containing Lactobacillus acidophilus , Lactobacillus rhamnosus , and Bifidobacterium species represent a reasonable first-line approach
When GIPRAs and GLP-1RAs were co-administered to obese mice, the combination significantly enhanced both appetite suppression and weight loss compared to monotherapy [33, 34]
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