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For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation

A balanced diet rich in vitamin B12 and other nutrients, along with regular physical activity, can support overall health and help maintain adequate B12 levels

Muscle mass remains preserved because AOD-9604 does not trigger catabolic pathways

While their primary use has been in anti-aging and muscle-building circles, increased GH can also lead to reduced body fat and increased lean muscle mass , making these peptides attractive for weight management