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To exclude any artifacts from an irreversible interaction between -arrestin and receptor in the PathHunter assay, we visualized GFP-tagged -arrestin-2 in MIN6B1-SNAP-GLP-1R cells, showing that exendin-4 and exendin-asp3, but not exendin-phe1, induce robust translocation to SNAP-GLP-1R-positive PM and endosomes (Fig

As a triple-agonist compound simultaneously engaging GLP-1, GIP, and glucagon receptors, retatrutide requires sophisticated dosing strategies that account for its unique pharmacokinetic profile, receptor occupancy dynamics, and dose-dependent adverse event spectrum

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Without pharmaceutical regulation, products vary enormously in purity, potency, and safety