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Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]
Later work examined NNMT inhibition combined with dietary changes in obese mice, reporting reductions in body weight, fat mass, and hepatic fat, alongside shifts in gut bacterial populations
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