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Studies in both animals and humans suggest DSIP modulates endogenous opioid peptide levels, stabilizing the beta-endorphin fluctuations that contribute to withdrawal symptoms (Dick et al., Eur J Pharmacol, 1984

Functional brain networks in the evaluation of patients with neurodegenerative disorders

High B12 without supplementation is a different clinical picture entirely

Similarly, another clinical study involving recreational exercisers found that oral lactate failed to improve aerobic capacity or lactate threshold, though it modestly increased work rate during a 20-minute time trial [242]