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View Study [5]"Efficacy and safety of CagriSema in type 2 diabetes" Frias JP et al., 2023 Finding: In people with type 2 diabetes, CagriSema achieved 15.6% weight loss versus 5.1% with semaglutide alone over 32 weeks, with comparable HbA1c reductions and good tolerability

FDA described the evidence as inconclusive and preliminary, with important methodological weaknesses

This neuroinflammation, triggered by activated glial cells, consequently contributes to neurotoxicity and therefore to neuronal dysfunction [165]

Similarly, quercetin and Coenzyme Q10 have been found to reverse mitochondrial dysfunction and decrease expression of pyroptosis markers in cyclophosphamide-induced POI mice (Wang et al., 2023c)