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The theoretical oncogenic risk is a significant unresolved safety question for any long-term human application
The induced liver progenitor cells differentiated into mature hepatocyte under induction of YAC, oncostatin M, and dexamethasone ( The quick loss of functions in isolated hepatocytes is one of the main hurdles in hepatocyte-based cell therapy
Both the nasal mucosa and lungs have large and highly vascularized surface areas for peptide absorption
Pain management: Some studies suggest analgesic (pain-relieving) properties, possibly through interaction with the opioidergic system
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