Obesity has multiple harmful effects on the body, says Jehan Bahrainwala, MD, a nephrologist and certified hypertension specialist at the Stanford Hypertension Center in California
Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity
[53] Iliceto S, Scrutinio D, Bruzzi P, DAmbrosio G, Boni L, Di Biase M, Biasco G, Hugenholtz PG, Rizzon P.J Am Coll Cardiol
Briefly, cells were fixed, processed, mounted on Epon stubs, polymerized at 60 C, and 70 nm sections cut en face with a diamond knife (DiATOME) in a Leica Ultracut UCT ultramicrotome before examination on an FEI Tecnai G2-Spirit TEM