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Identification of the mechanisms linking GLP-1R signaling to control of BP and the biology of renal artery and kidney protein expression extends our understanding of GLP-1 action and highlights the importance of the VSMC as a key GLP-1R + cell type contributing to the cardiorenal actions of GLP-1 medicines such as semaglutide

KEY TAKEAWAYS BY PRODUCT Ozempic dominated the GLP-1 agonists market owing to its high adoption for the management of type 2 diabetes, wide geographic availability, and a strong brand recognition

In a phase 3 trial (OASIS 4) comparing oral semaglutide 25 mg (the Wegovy pill) to placebo, the most common side effects were: Nausea Vomiting Constipation Indigestion (dyspepsia) Diarrhea Most side effects were mild or moderate and went away without stopping treatment

This rarest type of thyroid cancer makes up 3-4% of all human cases