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Indoleamine 2, 3-dioxygenase 1 (IDO1), indoleamine 2, 3-dioxygenase 2 (IDO2), and tryptophan-2, 3-dioxygenase (TDO) catalyze the rate-limiting step of tryptophan catabolism in the kynurenine pathway to consume tryptophan and produce kynurenine

The expression of the two genes encoding the enzyme of the second step of glutathione synthesis (GSHS) in the cytosol and chloroplast increased with increasing light intensity, and this change was accompanied by an increase in total glutathione contents in these cell compartments

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The resulting enhancement of connective tissue integrity makes it a key focus in musculoskeletal regeneration and aging-related bone metabolism research