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Setmelanotide, while mechanistically rational, lacks confirmatory trial data specifically for MC4R -deficient obesity and should be regarded as an exploratory option at present

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203 In contrast, paediatric patients ( n = 56) with episodic migraine treated with L-carnitine (50 mg per kg per day) experienced a reduction in migraine frequency, severity and duration that was comparable to the study arm receiving propranolol

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