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Using a Xenopus egg-extract model, which uncouples DNA repair from gene transcription 26 , we determined that IDH1 inhibition increased DSB formation and decreased HR, which was rescued by KG (Fig

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We detected two suggestively associated genetic variants with TgAb, rs6972286 close to ANKRD7 and LSM8 (P = 2.34 10 7 ) and rs756763 inside CA10 (P = 6.05 10 7 ), and one with TPOAb, rs12507813 positioned between TRIM61 and TRIM60 (P = 4.95 10 7 )

The researchers notably found that epithalamin not only produces direct antioxidant effects, but also stimulates the expression of antioxidant enzymes like superoxide dismutase and ceruloplasmin [10]