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The Phase 2 NEJM trial mapped this relationship across four dose tiers, and the Phase 3 TRIUMPH-4 data confirmed it at scale (Jastreboff et al., NEJM, 2023)
While this is a key research area, we propose that further investigations should verify whether GLP-1RAs may also affect cognitive and behavioral symptoms seen in psychosis, as suggested by their potential to influence neurobiological (for example, immune function) and neuropsychological (for example, reward) mechanisms that are known to be disrupted in psychotic illness
PD is the second most common NDD and is characterized by progressive loss of dopaminergic and specific non-dopaminergic neurons and the presence of Lewy bodies, which mainly consist of abnormally aggregated -synuclein
For the right client it is genuinely transformative, but I will always encourage you to look at sleep, diet and stress alongside it
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