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The findings deliver early evidence that semaglutide may offer a dual benefit, targeting obesity and key reproductive challenges associated with the condition, including irregular menstruation and impaired fertility. Clare Thompson, MBBS, BSc, nMRCGP Separately, a review of five randomized controlled trials presented at ENDO 2026 found that GLP-1 drugs, such as semaglutide and liraglutide, do not appear to harm male fertility and may even improve testosterone levels and sperm quality in some men with obesity

Research suggests this tri-agonist design may help explore mechanisms related to: Body weight regulation through appetite and satiety signaling

Long-term considerations for semaglutide B12 therapy Semaglutide is not a short-term medication

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