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Anecdotally, some users report needing to increase doses over time to maintain effects, which could indicate some degree of desensitization
Zhang ZF, Winton MI, Rainey C, et al
Occasionally eating 800 calories on a very low-appetite day may happen, but consistently eating below 1000 calories can make it harder to get enough protein, energy, fiber, and nutrients
(2013) Sex differences in lipid peroxidation and fatty acid levels in recent onset schizophrenia
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