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Abnormal changes in functional connectivity between the amygdala and frontal regions are associated with depression in Alzheimers disease

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This observation, together with the fact that 1 equivalent of DTT is not consumed in the reaction, indicated that intramolecular amide formation by nucleophilic attack of the AX side chain amino group to its electrophilic -lactam carbonyl, under these conditions, occurs only in the presence of DTT