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Furthermore, GltT-defective mutants, but not GltS-defective mutants, showed slightly reduced survival in HeLa cells (Monaco et al., 2006), and were significantly attenuated in a murine model of meningococcal meningitis (Colicchio et al., 2009) and in systemic murine models of infection (Li et al., 2009

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A biosimilar is a biological product that is similar to a reference biologic (usually the originally approved product) and for which there are no clinically meaningful differences in terms of safety, purity, and potency