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Risk Factors That Increase Benefit of SGLT-2 Inhibitors and GLP-1 Receptor Agonists In low-risk patients with less than three risk factors, SGLT-2 inhibitors still improve mortality, but absolute benefits are small
ABRs were recorded at seven frequencies (8, 12, 16, 20, 24, 28, and 32 kHz), with sound pulses presented at decreasing intensities (from 80 to 10 dB SPL in 5 dB SPL steps) and a 10-second pause between intensity levels
Furthermore, the absence of standardized formulations complicates dose uniformity and treatment reproducibility, as differences in concentration, excipients, or stability across preparations can materially influence therapeutic efficacy and safety outcomes