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We used the mean squared error (MSE) as our loss function and the Adam update 35 to optimize the loss with learning rate 1e3 on the first pre-training phosphoproteome dataset, and 1e4 on the other datasets

It is well established that metabolic changes drive microglial polarization, and a number of pathways, including hypoxia-inducible factor-1alpha (HIF-1), forkhead box P3 (FOXP3), and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, have been implicated in facilitating these effects [73]