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Increased levels of both 3-HSD and CYP11A1
However, liraglutide achieved this primarily through a pronounced reduction in palatable food intake, whereas sibutramine reduced consumption of both chow and palatable foods (Hansen et al., 2012)
Some patients also experience increased blood pressure shortly after administration, which is why its not recommended for individuals with uncontrolled hypertension
This has led to the development of GLP-1 receptor agonists (GLP-1 RAs), which have demonstrated favourable effects not only on metabolic variables but also on cardiovascular endpoints [4,5,6]
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