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This article examines the emerging evidence, proposed mechanisms involving brain reward pathways, and important safety considerations for clinicians and patients navigating this investigational area

The high heterogeneity observed for semaglutide further underscores the challenges of using genetic proxies for this drug

While GLP-1 receptor agonists have a lower risk of hypoglycaemia when used alone (compared to some other diabetes medications), this risk increases significantly when combined with sulfonylureas or insulin

For instance, an older patient managing multiple conditions may already be on several medications, and adding GLP-1s could complicate their regimen