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Beyond discrete pathway alterations, tumor cells dynamically rewire their intracellular signaling networks through feedback loops and pathway crosstalk to maintain essential survival outputs under therapeutic pressure
10.1186/s12964-020-0527-z 33 MelhemH.HansmannelF.BressenotA.Battaglia-HsuS
It promotes fibroblasts and collagen production Fibroblasts are biological cells needed to maintain the structural framework of body tissues like tendons and ligaments
Because intracellular cysteine level is usually below 100 M under the physiological conditions 18,19 , the interference of RT signals from cysteine is minimal
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