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For some people, the benefits of these medications do not outweigh the risks, as with any other pharmacologic intervention (e.g., adults who have previously had medullary thyroid cancer, in which they are contraindicated)

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If weekly tirzepatide injections produce double the weight loss of daily orforglipron pills, some people will gladly accept the needle

Stress triggers the release of cortisol, a hormone that can lead to increased cravings for high-calorie foods and may contribute to fat accumulation, particularly in the abdominal area