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Without ongoing lifestyle support, some patients regain weight over time, which is why Endocare focuses on sustainable habit change throughout treatment

Prevention desensitization: Cycle 5 days ON / 2 days OFF: Maintains sensitivity Step-up dosage Avoid starting at maximum dose Rotation Some protocols alternate weeks of treatment/rest Monitoring Measure IGF-1 every 4 weeks (indirect indicator) Studies up to 24 weeks without significant desensitization with the 5/2 protocol

The medication itself degrades when exposed to air or room temperature after the protective seal is broken

Should more than 5 days pass, patients should wait and take their next dose on the regularly scheduled day to maintain the once-weekly routine