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RCT conducted in patients with T2D showed that high doses of tirzepatide represent the most efficacious incretin-based anti-diabetes drug in terms of BW reduction 33 , sustaining the development of the SURMOUNT program to explore its efficacy and safety in the management of obesity 9
[20] [21] This controlled status applies regardless of the intended use
Human trial doses often range from 1 to 3 grams per day and show modest benefits for fat mass and performance in some groups
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