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The mechanism involves glycine exerting a hyperpolarizing effect on macrophages and other immune cells, inhibiting calcium influx through voltage-sensitive channels and thereby dampening their inflammatory activity
Hopefully, the MHRAs study will provide some needed insight on this possible side effect, including whether some people are more at risk for it than others.
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Some users find the steady-state from daily dosing actually produces fewer dramatic side effect episodes compared to the peak-and-trough pattern of weekly injections
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