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Serial blood samples were collected for PK analysis at pre-specified intervals up to 672 h after the final dose (pre-dose, 4, 6, 12, 24, 36, 48, 72, 120, 168, 336, and end-of-study at 672 h)
The samples were analysed by reversed-phase UPLC (RP-UPLC) at 214 nm and LCMS
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