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Energy production at the cellular level depends on key nutrients involved in metabolic pathways

Gene variants on genes such as MTHFR encoding methylenetetrahydrofolate reductase, MTR encoding methionine synthase, MTRR encoding methionine synthase reductase and CBS encoding cystathionine-B synthase in the methylation pathway can lead to a decreased ability to create sufficient methyl donor (SAMe) and may lead to disruptions in the SAMe:SAH ratio, thus altering methylation capacity and epigenetic regulation

s-glutathionylation) or factors, such as active site availability, substrate availability, and kinetic of the reaction might play a role in the stability of these complexes

However, multiple factors, including inflammation (Ahmad et al., 2022) and cerebral perfusion (Wolters et al., 2017) have been supported as early-stage biomarkers for neurodegenerative processes that are receptive to intervention prior to onset of clinically relevant loss in brain function