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Our results also align with a previous observation that resveratrol treatment is associated with Parasutterella blooming in stool samples

Substitution of these critical leucine residues to tryptophan eliminated binding affinity, highlighting the importance of maintaining key hydrophobic contacts of leucine side chains, and not general hydrophobicity, which is further exemplified by the evolutionary conservation of leucine residues in LD motifs 41

It is generally very well tolerated, non-sensitizing for most users, and is frequently marketed specifically to calm reactive or compromised skin

Positive findings have been reported across gut, muscle, tendon, ligament, nerve, and brain tissue which is unusual for a single compound