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It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2

This suggests potential synergy, but it doesnt mean you should demand both treatments

There are several reasons besides genetics that lead to your facelift results not lasting long

Once reconstituted, the blend should be refrigerated and used within the stability window appropriate for the compounds