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Therefore, overall, it appears that the diabetogenic risks commonly associated with diuretics are more strongly linked to hydrochlorothiazide (Padwal and Laupacis, 2004

The most important include Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and neurotrophin-3 (NT-3)

This leads to sagging, fine lines, and dullness