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However, Kaplan pointed out that this was mostly seen in lab rats, not humans

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A study suggested that in GCH1-deficient mice, BH4 could still accumulate with age, which was associated with the production of BH4 by specific gut microbiota, such as intestinal Actinobacteria [118]

Dave also believes that a healthier earth will hasten this process, and as an early proponent of regenerative agriculture, Dave was one of the first silicon valley entrepreneurs to construct his own 32-acre regenerative agriculture farm to demonstrate the power of food, ecology, and human development