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By using restricted cubic splines and IGF-1 serum concentrations as a continuous measure we did not find evidence for an association with ALS risk (p-value 0.21, Supplemental Fig
The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months
Enhanced Cognitive Health and Mood Promotes Neuroprotection: IGF-1 LR3 supports brain health by promoting neurogenesis (growth of new neurons), which is critical for cognitive health as women age
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