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Other significant considerations include: Injection site reactions (for subcutaneous formulations) Hypoglycaemia risk (particularly if used alongside other glucose-lowering medications) Pancreatitis (rare but serious) Gallbladder disease (including gallstones and cholecystitis) Dehydration leading to acute kidney injury (particularly with severe gastrointestinal side effects) Diabetic retinopathy complications (particularly noted with semaglutide in diabetes patients) Potential thyroid effects (medullary thyroid carcinoma risk in animal studies, though human relevance remains unclear) A Parkinson's-specific concern is that GLP-1 receptor agonists delay gastric emptying, which may further impair levodopa absorption and potentially worsen motor fluctuations or 'OFF' periods in patients on this medication
Gel pack management Gel packs lose effectiveness over time
During a slow, traditional weight loss process, the skin has ample time to adjust
Allergen immunotherapy (desensitisation) is available on the NHS for selected patients with confirmed IgE-mediated allergy who have not achieved adequate control with standard therapy, and can provide long-term relief without the need for ongoing medication
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