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Additionally, Tregs release IL-33, which directly stimulates myocyte regeneration, and facilitates the polarization of M1 macrophages toward the anti-inflammatory M2 phenotype, therefore reestablishing immune homeostasis (233)

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The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial

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doi: 10.1056/NEJMc1107080

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