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iron, thrombin, glutamate) directly induces neuronal hyperexcitability and network reorganization [71, 72], while albumin (Alb) leakage triggers TGF-mediated astrocytic activation, impairing potassium buffering and promoting excitatory synaptogenesis [73, 74]
[3] Medical uses [edit] In the European Union, afamelanotide is indicated for the prevention of phototoxicity in adults with erythropoietic protoporphyria
Neuronal loss can exacerbate the seizure severity (Zhang et al., 2002), and crucially, neuronal damage is directly associated with the initiation of epilepsy (Sayin et al., 2003)
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