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If you experience severe itching or irritation, discontinue use and let your doctor know

J Appl Microbiol 123(1):194203

For instance, in NSCLC, treatment with first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) often leads to the development of the EGFR T790M mutation, while third-generation inhibitors subsequently select for the C797S mutation, both of which confer resistance