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RNA-seq analysis revealed that DEGs between 0 mg/kg and 2 mg/kg anwuligan-treated mice were significantly enriched in several key pathways, including metabolic pathways, protein digestion and absorption, retinol metabolism, MAPK signaling pathway, PI3KAkt signaling pathway, Wnt signaling pathway, PPAR signaling pathway, BMP signaling pathway, and TGF-beta signaling pathway
GHK administered intraperitoneally at doses of 2.6, 26, and 260 g/ml/day reduced inflammatory cell infiltration, levels of TNF- and IL-6, as well as abolished bleomycin-induced elevation of TGF-beta in bleomycin-induced lung fibrosis in mice
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