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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis via the salvage pathway, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility [3]
A doctor may recommend vitamin B12 shots for people at risk of a deficiency or its complications, particularly if they are unable to take oral supplements
Vitamin B12 itself can stay stored in the liver for up to 3 to 5 years
Some suggest AOD 9604 may preferentially target stubborn fat cells (areas with higher fat storage) and may also exert beneficial effects on cartilage/ bone/ connective tissue (though those are more speculative)
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