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Another potential regulator of the chronic GSH adaptive response to CS exposure are the glutathione-S-transferases (GSTs) that conjugate GSH to xenobiotics for transport that could stimulate an increase in GSH synthesis to match GSH transport
Aging itself reduced synthesis capacity in cells Chronic oxidative stress from inflammation, poor diet, and environmental toxins Mitochondrial dysfunction your cellular energy factories become less efficient Nutrient deficiencies particularly B vitamins, selenium, and sulfur-containing amino acids Excessive alcohol consumption depletes glutathione rapidly Certain medications including acetaminophen, which consumes glutathione during metabolism The result
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