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Weight loss was associated with improvements in: Blood pressure Lipid profiles Sleep apnoea Joint pain Quality of life These findings led regulatory bodies to approve semaglutide (Wegovy) and tirzepatide (Zepbound) for obesity treatment, even in the absence of diabetes signalling a paradigm shift in how weight and metabolic risk are medically managed
Mccall also shares her personal connection to the topic through her daughter Rosie, highlighting the potential impact of these approaches for families facing health challenges
Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment
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